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A role for the periplasmic adaptor protein AcrA in vetting substrate access to the RND efflux transporter AcrB

Abstract Tripartite resistance-nodulation-division (RND) efflux pumps, such as AcrAB-TolC of Salmonella Typhimurium, contribute to antibiotic resistance and comprise an inner membrane RND-transporter, an outer membrane factor, and a periplasmic adaptor protein (PAP). The role of the PAP in the assem...

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Auteurs principaux: Ilyas Alav, Vassiliy N. Bavro, Jessica M. A. Blair
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2022-03-01
Collection:Scientific Reports
Accès en ligne:https://doi.org/10.1038/s41598-022-08903-9
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