Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension

Abstract Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosynthetic product ACh at appreciable concentrations to potentially act upon the endotheliu...

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Autors principals:	Andrew Stiegler, Jian-Hua Li, Vivek Shah, Tea Tsaava, Aisling Tynan, Huan Yang, Yehuda Tamari, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2021-10-01
Col·lecció:	Molecular Medicine
Matèries:	Hypertension Acetylcholine Choline acetyltransferase PEG-ChAT
Accés en línia:	https://doi.org/10.1186/s10020-021-00380-6
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