Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2
Connexins allow intercellular communication by forming gap junction channels (GJCs) between juxtaposed cells. Connexin26 (Cx26) can be regulated directly by CO2. This is proposed to be mediated through carbamylation of K125. We show that mutating K125 to glutamate, mimicking the negative charge of c...
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| Principais autores: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications Ltd
2024-06-01
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| 叢編: | eLife |
| 主題: | |
| 在線閱讀: | https://elifesciences.org/articles/93686 |
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