Growth hormone combined with estrogen improves intrauterine adhesion fibrosis by downregulating endometrial microbial citraconic acid to target β-catenin protein

ABSTRACT Intrauterine adhesions (IUAs) are a major cause of secondary infertility. This study aimed to investigate the therapeutic effects and mechanisms of combined recombinant rat growth hormone (rrGH) and estrogen therapy on endometrial fibrosis in IUA rats. Our findings revealed that IUA rats ex...

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Autori principali:	Yuhua Zeng, Yanfei Yang, Fei Zeng, Qing Feng
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2025-07-01
Serie:	mSystems
Soggetti:	intrauterine adhesions growth hormone estrogen endometrial microbiota citraconic acid β-catenin pathway
Accesso online:	https://journals.asm.org/doi/10.1128/msystems.01692-24
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