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Tetrandrine activates STING/TBK1/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer

The efficacy of PD-1 therapy in non-small cell lung cancer (NSCLC) patients remains unsatisfactory. Activating the STING pathway is a promising strategy to improve PD-1 inhibitor efficacy. Here, we found tetrandrine (TET), an anti-tumor compound extracted from a medicinal plant commonly used in trad...

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Principais autores: Yan Tan, Qiancheng Zhu, Meilin Yang, Fan Yang, Qi Zeng, Zebo Jiang, Dan Li
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-09-01
Serier:Pharmacological Research
Fag:
Tetrandrine
Anti-PD-1 immunotherapy
Non-small cell lung cancer
In vivo imaging
STING pathway
Online adgang:http://www.sciencedirect.com/science/article/pii/S1043661824002597
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