Tetrandrine activates STING/TBK1/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer

The efficacy of PD-1 therapy in non-small cell lung cancer (NSCLC) patients remains unsatisfactory. Activating the STING pathway is a promising strategy to improve PD-1 inhibitor efficacy. Here, we found tetrandrine (TET), an anti-tumor compound extracted from a medicinal plant commonly used in trad...

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Autores principales:	Yan Tan, Qiancheng Zhu, Meilin Yang, Fan Yang, Qi Zeng, Zebo Jiang, Dan Li
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2024-09-01
Colección:	Pharmacological Research
Materias:	Tetrandrine Anti-PD-1 immunotherapy Non-small cell lung cancer In vivo imaging STING pathway
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S1043661824002597
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