Could Cytochrome P450 2D6, 3A4 and 3A5 Polymorphisms Explain the Variability in Clinical Response to Clomiphene Citrate of Anovulatory PCOS Women?

IntroductionCytochrome P450 2D6, 3A4 and 3A5 are involved in the metabolism of many drugs. These enzymes have a genetic polymorphism responsible for different metabolic phenotypes. They play a role in the metabolism of clomiphene citrate (CC), which is used to induce ovulation. Response to CC treatm...

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Hlavní autoři:	Camille Robin, Benjamin Hennart, Franck Broly, Philippine Gruchala, Geoffroy Robin, Sophie Catteau-Jonard
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-10-01
Edice:	Frontiers in Endocrinology
Témata:	clomiphene citrate cytochrome P 450 2D6 anti-Müllerian hormone (AMH) ovulation induction polycystic ovary syndrome (PCOS)
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fendo.2021.718917/full
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