Could Cytochrome P450 2D6, 3A4 and 3A5 Polymorphisms Explain the Variability in Clinical Response to Clomiphene Citrate of Anovulatory PCOS Women?

IntroductionCytochrome P450 2D6, 3A4 and 3A5 are involved in the metabolism of many drugs. These enzymes have a genetic polymorphism responsible for different metabolic phenotypes. They play a role in the metabolism of clomiphene citrate (CC), which is used to induce ovulation. Response to CC treatm...

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Bibliografische Detailangaben

Hauptverfasser:	Camille Robin, Benjamin Hennart, Franck Broly, Philippine Gruchala, Geoffroy Robin, Sophie Catteau-Jonard
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-10-01
Schriftenreihe:	Frontiers in Endocrinology
Schlagworte:	clomiphene citrate cytochrome P 450 2D6 anti-Müllerian hormone (AMH) ovulation induction polycystic ovary syndrome (PCOS)
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fendo.2021.718917/full
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