An integrated cell and medium engineering approach for production of a nanobody fusion in Saccharomyces cerevisiae

Abstract Saccharomyces cerevisiae is an established production host for therapeutic proteins; many of those are small proteins such as insulin or glucagon-like peptide-1 (GLP-1) analogs. Contrastingly, proteins of higher molecular weight, foremost antibodies, did not reach the market due, among othe...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Laura R. K. Niemelä, Lotta-Mari Kirjavainen, Hendrikje C. J. Kozlowski, Heidi Salminen, Alexander D. Frey
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer 2026-01-01
Serier:	Applied Microbiology and Biotechnology
Fag:	Saccharomyces cerevisiae Chemical chaperones Small-scale production system Medium optimization Recombinant antibody production Chimeric nanobody-Fc fusion protein
Online adgang:	https://doi.org/10.1007/s00253-025-13700-1
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!