An integrated cell and medium engineering approach for production of a nanobody fusion in Saccharomyces cerevisiae

Abstract Saccharomyces cerevisiae is an established production host for therapeutic proteins; many of those are small proteins such as insulin or glucagon-like peptide-1 (GLP-1) analogs. Contrastingly, proteins of higher molecular weight, foremost antibodies, did not reach the market due, among othe...

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Principais autores:	Laura R. K. Niemelä, Lotta-Mari Kirjavainen, Hendrikje C. J. Kozlowski, Heidi Salminen, Alexander D. Frey
Formato:	Artigo
Idioma:	Inglês
Publicado:	Springer 2026-01-01
Series:	Applied Microbiology and Biotechnology
Assuntos:	Saccharomyces cerevisiae Chemical chaperones Small-scale production system Medium optimization Recombinant antibody production Chimeric nanobody-Fc fusion protein
Acceso en liña:	https://doi.org/10.1007/s00253-025-13700-1
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