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Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1

Myotonic dystrophy type I (DM1) is a multi-system, autosomal dominant disorder caused by expansion of a CTG repeat sequence in the 3′UTR of the DMPK gene. The size of the repeat sequence correlates with age at onset and disease severity, with large repeats leading to congenital forms of DM1 associat...

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Uloženo v:
Hlavní autoři: Peter K. Todd, Feras Y. Ackall, Junguk Hur, Kush Sharma, Henry L. Paulson, James J. Dowling
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2014-01-01
Edice:Disease Models & Mechanisms
Témata:
Muscleblind
CUG repeat
Nucleotide repeat
Neurodegeneration
On-line přístup:http://dmm.biologists.org/content/7/1/143
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