Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53

Abstract Purpose The present study aimed to explore the anticancer activity of hirsuteine (HST), an indole alkaloid from the traditional Chinese herbal medicine Uncaria rhynchophylla, against colorectal cancer (CRC) and the underlining mechanism. Methods MTT, colony formation, flow cytometry and MDC...

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Prif Awduron:	Yan Zhang, Tingting Guo, Shurong Li, Zehao Ren, Shan Gao, Hao Lu, Xuelan Ma, Donghui Liu, Yao Liu, Dexin Kong, Yuling Qiu
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Springer 2023-05-01
Cyfres:	Discover Oncology
Pynciau:	Hirsuteine Opposite modulation Wild-type p53 Mutant p53 Colorectal cancer
Mynediad Ar-lein:	https://doi.org/10.1007/s12672-023-00688-1
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