Outer membrane vesicles-based nano-regulator for cancer immunotherapy by modulating neutrophils N1 polarization and hitchhiking delivery

Abstract Efficient eradication of cancer cells and enhanced tumor accumulation of drug via immune cells represent promising strategies for cancer treatment, yet they remain significant challenges. Inspired by neutrophils (NEs), we designed a novel nano-regulator (OMV@PCB NPs) to improve cancer thera...

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Autori principali:	Xiaoning Liu, Qun Niu, Haoxiang Yang, Tongyao Du, Yichen Liu, Hengqi Zhou, Shuqi Wang, Lingli Shen, Xuannian Wang, Gaiping Zhang, Hua He
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-10-01
Serie:	Journal of Nanobiotechnology
Soggetti:	Neutrophil polarization TGF-β inhibitor Outer membrane vesicles (OMVs) Hitchhiking delivery Cancer immunotherapy
Accesso online:	https://doi.org/10.1186/s12951-025-03658-7
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