CYLD suppression enhances the pro-inflammatory effects and hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes by enhancing NF-κB activation

Abstract Background Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) actively drive joint inflammation and degradation by producing inflammatory cytokines and matrix-degrading molecules, making them key factors in the pathogenesis of RA. Cylindromatosis (CYLD) is a tumor suppressor that d...

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Autors principals:	Le-meng Zhang, Jing-Jing Zhou, Chun-lei Luo
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2018-10-01
Col·lecció:	Arthritis Research & Therapy
Matèries:	Rheumatoid arthritis (RA) Cylindromatosis (CYLD) Fibroblast-like synoviocyte (FLS) Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) Pro-inflammatory cytokines Hyperproliferation
Accés en línia:	http://link.springer.com/article/10.1186/s13075-018-1722-9
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