Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a critical role in RA progression, the increase of...

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Autors principals:	Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang, Dongqian Cui, Tingting Luo, Yu Zhang, Qian Liu, Hao Li, Chun Wang, Dexiang Xu, Yang Ma, Wei Wei
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-07-01
Col·lecció:	Acta Pharmaceutica Sinica B
Matèries:	CP-25 Rheumatoid arthritis Fibroblast-like synoviocyte MH7A G protein coupled receptor kinase 2 Prostaglandin E4 receptor
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211383521000186
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