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Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a critical role in RA progression, the increase of...

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Principais autores: Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang, Dongqian Cui, Tingting Luo, Yu Zhang, Qian Liu, Hao Li, Chun Wang, Dexiang Xu, Yang Ma, Wei Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-07-01
coleção:Acta Pharmaceutica Sinica B
Assuntos:
CP-25
Rheumatoid arthritis
Fibroblast-like synoviocyte
MH7A
G protein coupled receptor kinase 2
Prostaglandin E4 receptor
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211383521000186
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