Empagliflozin improves renal ischemia–reperfusion injury by reducing inflammation and enhancing mitochondrial fusion through AMPK–OPA1 pathway promotion

Abstract Background Renal ischemia–reperfusion injury (IRI) is one reason for renal transplantation failure. Recent studies have shown that mitochondrial dynamics is closely related to IRI, and that inhibition or reversal of mitochondrial division protects organs against IRI. Optic atrophy protein 1...

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Principais autores:	Wenbo Yang, Xiaoli Li, Liujie He, Shuyang Zhu, Shicong Lai, Xiaopeng Zhang, Zixiong Huang, Biyue Yu, Chunping Cui, Qiang Wang
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2023-05-01
Series:	Cellular & Molecular Biology Letters
Assuntos:	Renal ischemia–reperfusion injury Empagliflozin SGLT2i Inflammation Mitochondrial dynamics OPA1
Acceso en liña:	https://doi.org/10.1186/s11658-023-00457-6
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