The GDP-Bound State of Mitochondrial Mfn1 Induces Membrane Adhesion of Apposing Lipid Vesicles through a Cooperative Binding Mechanism

Mitochondria are double-membrane organelles that continuously undergo fission and fusion. Outer mitochondrial membrane fusion is mediated by the membrane proteins mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2), carrying a GTP hydrolyzing domain (GTPase) and two coiled-coil repeats. The detailed mechanism...

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Autors principals:	Andrés Tolosa-Díaz, Víctor G. Almendro-Vedia, Paolo Natale, Iván López-Montero
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2020-07-01
Col·lecció:	Biomolecules
Matèries:	mitochondria membrane fusion GTPase mitofusin 1 giant vesicles
Accés en línia:	https://www.mdpi.com/2218-273X/10/7/1085
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