Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington’s disease

Abstract Background Huntington’s disease (HD) is marked by a CAG-repeat expansion in the huntingtin gene that causes neuronal dysfunction and loss, affecting mainly the striatum and the cortex. Alterations in the neurovascular coupling system have been shown to lead to dysregulated energy supply to...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Tamara Vasilkovska, Somaie Salajeghe, Verdi Vanreusel, Johan Van Audekerke, Marlies Verschuuren, Lydiane Hirschler, Jan Warnking, Isabel Pintelon, Dorian Pustina, Roger Cachope, Ladislav Mrzljak, Ignacio Muñoz-Sanjuan, Emmanuel L. Barbier, Winnok H. De Vos, Annemie Van der Linden, Marleen Verhoye
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-04-01
Schriftenreihe:	Journal of Biomedical Science
Schlagworte:	Huntington’s disease Brain perfusion Cerebral blood flow Cerebrovascular reactivity Blood vessels
Online-Zugang:	https://doi.org/10.1186/s12929-024-01028-3
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