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Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington’s disease

Abstract Background Huntington’s disease (HD) is marked by a CAG-repeat expansion in the huntingtin gene that causes neuronal dysfunction and loss, affecting mainly the striatum and the cortex. Alterations in the neurovascular coupling system have been shown to lead to dysregulated energy supply to...

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Furkejuvvon:
Váldodahkkit: Tamara Vasilkovska, Somaie Salajeghe, Verdi Vanreusel, Johan Van Audekerke, Marlies Verschuuren, Lydiane Hirschler, Jan Warnking, Isabel Pintelon, Dorian Pustina, Roger Cachope, Ladislav Mrzljak, Ignacio Muñoz-Sanjuan, Emmanuel L. Barbier, Winnok H. De Vos, Annemie Van der Linden, Marleen Verhoye
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2024-04-01
Ráidu:Journal of Biomedical Science
Fáttát:
Huntington’s disease
Brain perfusion
Cerebral blood flow
Cerebrovascular reactivity
Blood vessels
Liŋkkat:https://doi.org/10.1186/s12929-024-01028-3
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