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Fibrillarin-mediated ribosomal RNA maturation is a novel therapeutic vulnerability in triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) remains one of the most challenging breast cancer subtypes to treat due to the lack of effective therapeutic options. Ribosome biogenesis has recently emerged as a promising therapeutic target across various cancers. Despite the current target...

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Principais autores: Camille Jouines, Piero Lo Monaco, Angéline Gaucherot, Julie Radermecker, Caroline Isaac, Fleur Bourdelais, Marie-Ambre Monet, Marion Meyer, Mounira Chalabi-Dchar, Flora Nguyen Van Long, Laury Baillon, Carine Froment, Julien Marcoux, Christophe Vanbelle, Tanguy Fenouil, Sébastien Durand, Stéphane Giraud, Jean-Jacques Diaz, Virginie Marcel, Frédéric Catez
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-11-01
coleção:Breast Cancer Research
Assuntos:
Ribosome biogenesis
rRNA maturation
Fibrillarin
Breast cancer
Therapeutic target
Acesso em linha:https://doi.org/10.1186/s13058-025-02163-x
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