Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-Gq/11 protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells

This study examined the possible involvement of Ca2+-sensing receptor (CaSR) in nitric oxide (NO) production in human vascular endothelial cells. Extracellular Ca2+ elevated the intracellular Ca2+ concentration, the endothelial NO synthase (eNOS) phosphorylation level, and NO release from the cells....

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Autori principali:	Takahiro Horinouchi, Yuichi Mazaki, Koji Terada, Soichi Miwa
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2020-08-01
Serie:	Journal of Pharmacological Sciences
Soggetti:	Ca2+-sensing receptor Endothelial nitric oxide synthase Extracellular Ca2+
Accesso online:	http://www.sciencedirect.com/science/article/pii/S134786131934174X
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