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Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-Gq/11 protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells

This study examined the possible involvement of Ca2+-sensing receptor (CaSR) in nitric oxide (NO) production in human vascular endothelial cells. Extracellular Ca2+ elevated the intracellular Ca2+ concentration, the endothelial NO synthase (eNOS) phosphorylation level, and NO release from the cells....

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Principais autores: Takahiro Horinouchi, Yuichi Mazaki, Koji Terada, Soichi Miwa
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-08-01
Serier:Journal of Pharmacological Sciences
Fag:
Ca2+-sensing receptor
Endothelial nitric oxide synthase
Extracellular Ca2+
Online adgang:http://www.sciencedirect.com/science/article/pii/S134786131934174X
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