Rational engineering of a thermostable α-oxoamine synthase biocatalyst expands the substrate scope and synthetic applicability

Abstract Carbon-carbon bond formation is one of the key pillars of organic synthesis. Green, selective and efficient biocatalytic methods for such are therefore highly desirable. The α-oxoamine synthases (AOSs) are a class of pyridoxal 5’-phosphate (PLP)-dependent, irreversible, carbon-carbon bond-f...

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Autors principals:	Ben Ashley, Sam Mathew, Mariyah Sajjad, Yaoyi Zhu, Nikita Novikovs, Arnaud Baslé, Jon Marles-Wright, Dominic J. Campopiano
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-03-01
Col·lecció:	Communications Chemistry
Accés en línia:	https://doi.org/10.1038/s42004-025-01448-8
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