Molecular Basis of NDT-Mediated Activation of Nucleoside-Based Prodrugs and Application in Suicide Gene Therapy

Herein we report the first proof for the application of type II 2′-deoxyribosyltransferase from <i>Lactobacillus delbrueckii</i> (<i>Ld</i>NDT) in suicide gene therapy for cancer treatment. To this end, we first confirm the hydrolytic ability of <i>Ld</i>NDT over the nucleoside-based prodrugs 2′-deo...

Descripció completa

Dades bibliogràfiques

Autors principals:	Javier Acosta, Elena Pérez, Pedro A. Sánchez-Murcia, Cristina Fillat, Jesús Fernández-Lucas
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2021-01-01
Col·lecció:	Biomolecules
Matèries:	chemotherapy suicide gene therapy nucleoside analogues 2′-deoxyribosyltransferase structural bioinformatics molecular dynamics
Accés en línia:	https://www.mdpi.com/2218-273X/11/1/120
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!