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Molecular Basis of NDT-Mediated Activation of Nucleoside-Based Prodrugs and Application in Suicide Gene Therapy

Herein we report the first proof for the application of type II 2′-deoxyribosyltransferase from <i>Lactobacillus delbrueckii</i> (<i>Ld</i>NDT) in suicide gene therapy for cancer treatment. To this end, we first confirm the hydrolytic ability of <i>Ld</i>NDT over the nucleoside-based prodrugs 2′-deo...

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Hoofdauteurs: Javier Acosta, Elena Pérez, Pedro A. Sánchez-Murcia, Cristina Fillat, Jesús Fernández-Lucas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2021-01-01
Reeks:Biomolecules
Onderwerpen:
chemotherapy
suicide gene therapy
nucleoside analogues
2′-deoxyribosyltransferase
structural bioinformatics
molecular dynamics
Online toegang:https://www.mdpi.com/2218-273X/11/1/120
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