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Integrated Lymphopenia Analysis in Younger and Older Patients With Multiple Sclerosis Treated With Cladribine Tablets

Cladribine tablets (CladT) preferentially reduce B and T lymphocyte levels. As aging is associated with a decline in immune function, the effect of CladT on lymphocyte levels may differ by age. This post hoc analysis combined data from the Phase 3 CLARITY, CLARITY Extension, and ORACLE-MS studies to...

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Principais autores: Gavin Giovannoni, Patricia K. Coyle, Patrick Vermersch, Bryan Walker, Julie Aldridge, Axel Nolting, Andrew Galazka, Caroline Lemieux, Thomas P. Leist
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-12-01
coleção:Frontiers in Immunology
Assuntos:
cladribine tablets
lymphocyte subsets
lymphopenia
multiple sclerosis
age
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2021.763433/full
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