A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction

Summary: Myocardial infarction (MI) results in aberrant cardiac metabolism, but no therapeutics have been designed to target cardiac metabolism to enhance heart repair. We engineer a humanized monoclonal antibody against the ectonucleotidase ENPP1 (hENPP1mAb) that targets metabolic crosstalk in the...

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Autors principals:	Shen Li, Bo Tao, Jijun Wan, Enca Montecino-Rodriguez, Ping Wang, Feiyang Ma, Baiming Sun, Yiqian Gu, Sivakumar Ramadoss, Lianjiu Su, Qihao Sun, Johanna Ten Hoeve, Linsey Stiles, Jeffrey Collins, R. Michael van Dam, Mikayla Tamboline, Richard Taschereau, Orian Shirihai, Douglas B. Kitchen, Matteo Pellegrini, Thomas Graeber, Kenneth Dorshkind, Shili Xu, Arjun Deb
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-11-01
Col·lecció:	Cell Reports Medicine
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2666379124005421
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