Cyanide overproduction impairs cellular bioenergetics in Down syndrome
Cyanide exerts its toxic effects primarily by inhibiting mitochondrial Complex IV (Cytochrome c oxidase, CCOx). Recent studies have shown that mammalian cells can endogenously produce cyanide from glycine via a lysosomal pathway. At low concentrations, cyanide may play regulatory roles, but at highe...
Gardado en:
| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2025-10-01
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| Series: | Neurotherapeutics |
| Assuntos: | |
| Acceso en liña: | http://www.sciencedirect.com/science/article/pii/S1878747925001977 |
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