Cyanide overproduction impairs cellular bioenergetics in Down syndrome
Cyanide exerts its toxic effects primarily by inhibiting mitochondrial Complex IV (Cytochrome c oxidase, CCOx). Recent studies have shown that mammalian cells can endogenously produce cyanide from glycine via a lysosomal pathway. At low concentrations, cyanide may play regulatory roles, but at highe...
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| Principais autores: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2025-10-01
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| Serier: | Neurotherapeutics |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S1878747925001977 |
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