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Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire

Adaptive immunity depends on diverse T cell receptor repertoires generated by variable, diversity, and joining (V[D]J) recombination. Here, we define the principles by which combinatorial diversity is generated in the murine Tcra repertoire. Tcra and Tcrd gene segments share the Tcra-Tcrd locus, wit...

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Autores principales: Zachary M. Carico, Kingshuk Roy Choudhury, Baojun Zhang, Yuan Zhuang, Michael S. Krangel
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2017-06-01
Colección:Cell Reports
Materias:
antigen receptor
chromatin conformation
mucosa-associated invariant T cells
MAIT cells
T cell receptor alpha
T cell receptor delta
T cell development
TCR repertoire
T cell receptor repertoire
V(D)J recombination
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S2211124717306873
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