Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire

Adaptive immunity depends on diverse T cell receptor repertoires generated by variable, diversity, and joining (V[D]J) recombination. Here, we define the principles by which combinatorial diversity is generated in the murine Tcra repertoire. Tcra and Tcrd gene segments share the Tcra-Tcrd locus, wit...

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Autors principals:	Zachary M. Carico, Kingshuk Roy Choudhury, Baojun Zhang, Yuan Zhuang, Michael S. Krangel
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2017-06-01
Col·lecció:	Cell Reports
Matèries:	antigen receptor chromatin conformation mucosa-associated invariant T cells MAIT cells T cell receptor alpha T cell receptor delta T cell development TCR repertoire T cell receptor repertoire V(D)J recombination
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124717306873
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