Amoxicillin Haptenation of α-Enolase is Modulated by Active Site Occupancy and Acetylation

Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the modification of proteins by covalent binding of the drug (haptenation). Hence, i...

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主要な著者:	Juan M. González-Morena, Francisco J. Sánchez-Gómez, Yolanda Vida, Ezequiel Pérez-Inestrosa, María Salas, María I. Montañez, Alessandra Altomare, Giancarlo Aldini, María A. Pajares, Dolores Pérez-Sala
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2022-01-01
シリーズ:	Frontiers in Pharmacology
主題:	beta-lactam antibiotics protein modification by drugs mass spectrometry posttranslational modification acetylation allergic responses to drugs
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphar.2021.807742/full
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