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Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency

Serum and cellular proteins are targets for the formation of adducts with the β-lactam antibiotic amoxicillin. This process could be important for the development of adverse, and in particular, allergic reactions to this antibiotic. In studies exploring protein haptenation by amoxicillin, we observe...

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Principais autores: María A. Pajares, Tahl Zimmerman, Francisco J. Sánchez-Gómez, Adriana Ariza, María J. Torres, Miguel Blanca, F. Javier Cañada, María I. Montañez, Dolores Pérez-Sala
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-03-01
coleção:Frontiers in Pharmacology
Assuntos:
amoxicillin
β-lactam antibiotics
inactivation mechanism
redox regulation
protein adducts
thiol groups
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2020.00189/full
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