Predictive value of the maternal alpha-fetoprotein variant, L2, during the first trimester of pregnancy screening for fetal trisomy 21, trisomy 18, and neural tube defects

Abstract Background To assess the predictive usefulness of maternal serum alpha fetoprotein variant L2 (AFP-L2) for fetal trisomy 21, trisomy 18, and neural tube abnormalities (NTDs) in early pregnancy screening. Methods This retrospective case-control study including 155 fetuses diagnosed with tris...

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Autores principales:	Yiming Chen, Wenwen Ning, Caihe Wen, Linyuan Gu, Xuelian Chu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-08-01
Colección:	BMC Pregnancy and Childbirth
Materias:	Early pregnancy Prenatal screening Alpha-fetoprotein variant L2 Trisomy 21 Trisomy 18 Neural tube defects
Acceso en línea:	https://doi.org/10.1186/s12884-025-07893-6
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