USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion

Abstract Human FAN1 is a structure-specific endonuclease implicated in the repair of DNA interstrand crosslinks (ICLs) and the excision of extrahelical CAG repeats–whose pathological expansion underlies Huntington’s disease (HD), a progressive and currently incurable neurodegenerative disorder. Howe...

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Principais autores:	Giulio Collotta, Marco Gatti, Irina-Maria Ungureanu, Vanessa van Ackeren, Emilie Rannou, Francesca Vivalda, Diego Gomez Vieito, Keri M. Fishwick, Christine von Aesch, Antonio Porro, Kyra Ungerleider, Ailin Heidari, Raphaël Guérois, Rachel J. Harding, Sylvain Bischof, Gabriel Balmus, Alessandro A. Sartori
格式:	Artigo
語言:	Inglês
出版:	Nature Portfolio 2026-03-01
叢編:	Nature Communications
在線閱讀:	https://doi.org/10.1038/s41467-026-70051-9
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