Systematic discovery of motif-based interactions of the auxiliary domains of USP family deubiquitinases

Abstract The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity is thought to be mediated by the recognition of the ubiquitnated protein itself. In addition...

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Hlavní autoři:	Aimiliani Konstantinou, Alicia Córdova-Pérez, Julia K. Varga, Priyanka Madhu, Leandro Simonetti, Maximilian Vieler, Ryosuke Ishimura, Frederic Lamoliatte, Ora Schueler-Furman, Norman E. Davey, Yogesh Kulathu, Ylva Ivarsson
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-05-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-026-73047-7
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