The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation

Severe COVID-19 patients exhibit impaired IFN-I response due to decreased IFN-β production, allowing persistent viral load and exacerbated inflammation. While the SARS-CoV-2 nucleocapsid (N) protein has been implicated in inhibiting innate immunity by interfering with IFN-β signaling, the specific u...

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Principais autores:	Congcong Huang, Yiping Yin, Pan Pan, Yanping Huang, Siwei Chen, Junkai Chen, Ju Wang, Guoqing Xu, Xuan Tao, Xiao Xiao, Jian Li, Jing Yang, Zhixiong Jin, Bei Li, Zhaohui Tong, Weixing Du, Long Liu, Zhixin Liu
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2023-11-01
叢編:	Viruses
主題:	SARS-CoV-2 nucleocapsid protein UBC9 MAVS SUMOylation ubiquitination
在線閱讀:	https://www.mdpi.com/1999-4915/15/12/2304
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