Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease

Amyotrophic lateral sclerosis (ALS) and motor neuron diseases (MNDs) are progressive neurodegenerative diseases that affect nerve cells in the brain affecting upper and lower motor neurons (UMNs/LMNs), brain stem and spinal cord. The clinical phenotype is characterized by loss of motor neurons (MNs)...

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Detalhes bibliográficos

Autor principal:	Manoj Kumar Jaiswal
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wolters Kluwer Medknow Publications 2017-01-01
coleção:	Neural Regeneration Research
Assuntos:	iPSCs; stem cells; human patients; ALS; mitochondria; motor neuron disease; disease modeling; neurodegeneration; gene editing; transplantation; drug screening
Acesso em linha:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=5;spage=723;epage=736;aulast=Jaiswal
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