Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease

Amyotrophic lateral sclerosis (ALS) and motor neuron diseases (MNDs) are progressive neurodegenerative diseases that affect nerve cells in the brain affecting upper and lower motor neurons (UMNs/LMNs), brain stem and spinal cord. The clinical phenotype is characterized by loss of motor neurons (MNs)...

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書誌詳細

第一著者:	Manoj Kumar Jaiswal
フォーマット:	Artigo
言語:	Inglês
出版事項:	Wolters Kluwer Medknow Publications 2017-01-01
シリーズ:	Neural Regeneration Research
主題:	iPSCs; stem cells; human patients; ALS; mitochondria; motor neuron disease; disease modeling; neurodegeneration; gene editing; transplantation; drug screening
オンライン･アクセス:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=5;spage=723;epage=736;aulast=Jaiswal
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