A druggable conformational switch in the c-MYC transactivation domain

Abstract The c-MYC oncogene is activated in over 70% of all human cancers. The intrinsic disorder of the c-MYC transcription factor facilitates molecular interactions that regulate numerous biological pathways, but severely limits efforts to target its function for cancer therapy. Here, we use a red...

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Autori principali:	Dilraj Lama, Thibault Vosselman, Cagla Sahin, Judit Liaño-Pons, Carmine P. Cerrato, Lennart Nilsson, Kaare Teilum, David P. Lane, Michael Landreh, Marie Arsenian Henriksson
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-02-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-024-45826-7
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