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A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain.

The c-Myc protein is a transcription factor with an N-terminal transcriptional regulatory domain and C-terminal oligomerization and DNA-binding motifs. Previous studies have demonstrated that p107, a protein related to the retinoblastoma protein, binds to the c-Myc transcriptional activation domain...

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Sparad:
I publikationen:Mol Cell Biol
Huvudupphov: Hoang, A T, Lutterbach, B, Lewis, B C, Yano, T, Chou, T Y, Barrett, J F, Raffeld, M, Hann, S R, Dang, C V
Materialtyp: Artigo
Språk:Inglês
Utgiven: Taylor & Francis 1995
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230642/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7623799/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.8.4031
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