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Mechanism of ribosome rescue by ArfA and RF2

ArfA rescues ribosomes stalled on truncated mRNAs by recruiting release factor RF2, which normally binds stop codons to catalyze peptide release. We report two 3.2 Å resolution cryo-EM structures – determined from a single sample – of the 70S ribosome with ArfA•RF2 in the A site. In both states, the...

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Huvudupphov: Gabriel Demo, Egor Svidritskiy, Rohini Madireddy, Ruben Diaz-Avalos, Timothy Grant, Nikolaus Grigorieff, Duncan Sousa, Andrei A Korostelev
Materialtyp: Artigo
Språk:Inglês
Utgiven: eLife Sciences Publications Ltd 2017-03-01
Serie:eLife
Ämnen:
stalled ribosome
release factor 2
ArfA
ribosome rescue
stop-codon-independent termination
Länkar:https://elifesciences.org/articles/23687
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