Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria

Similar to DNA replication, translation of the genetic code by the ribosome is hypothesized to be exceptionally sensitive to small chemical changes to its template mRNA. Here we show that the addition of common alkylating agents to growing cultures of Escherichia coli leads to the accumulation of se...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Erica N Thomas, Kyusik Q Kim, Emily P McHugh, Thomas Marcinkiewicz, Hani S Zaher
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	eLife Sciences Publications Ltd 2020-09-01
Цуврал:	eLife
Нөхцлүүд:	ribosome alkylation RNA damage tmRNA trans translation quality control
Онлайн хандалт:	https://elifesciences.org/articles/61984
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!