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Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria

Similar to DNA replication, translation of the genetic code by the ribosome is hypothesized to be exceptionally sensitive to small chemical changes to its template mRNA. Here we show that the addition of common alkylating agents to growing cultures of Escherichia coli leads to the accumulation of se...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Erica N Thomas, Kyusik Q Kim, Emily P McHugh, Thomas Marcinkiewicz, Hani S Zaher
Hōputu: Artigo
Reo:Inglês
I whakaputaina: eLife Sciences Publications Ltd 2020-09-01
Rangatū:eLife
Ngā marau:
Urunga tuihono:https://elifesciences.org/articles/61984
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