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Structure of a AAA+ unfoldase in the process of unfolding substrate

AAA+ unfoldases are thought to unfold substrate through the central pore of their hexameric structures, but how this process occurs is not known. VAT, the Thermoplasma acidophilum homologue of eukaryotic CDC48/p97, works in conjunction with the proteasome to degrade misfolded or damaged proteins. We...

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Autori principali: Zev A Ripstein, Rui Huang, Rafal Augustyniak, Lewis E Kay, John L Rubinstein
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2017-04-01
Serie:eLife
Soggetti:
Cryo-EM
AAA+
VAT
unfolding
ATPase
Thermoplasma acidophilum
Accesso online:https://elifesciences.org/articles/25754
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