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Development and Validation of HPLC-DAD Method for the Determination of Favipiravir and Studying the Impact of Vitamin C on the Pharmacokinetics of COVID-19 Antiviral Drug Favipiravir

A novel, sensitive, and low-cost HPLC method for the rapid determination of favipiravir (FVR) in rat plasma was developed and validated, and the effect of vitamin C on FVR pharmacokinetic parameters was investigated. FVR and oxcarbazepine (IS) were separated using a mobile phase of 50% acetonitrile...

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Principais autores: Mohammad Hailat, Israa Al-Ani, Zainab Zakareia, Ramadan Al-Shdefat, Osaid Al-Meanazel, Md. Khalid Anwer, Mohammed Hamad, Walid Abu Rayyan, Riad Awad, Wael Abu Dayyih
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-10-01
Serier:Separations
Fag:
favipiravir
vitamin C
HPLC
validation
plasma
pharmacokinetics
Online adgang:https://www.mdpi.com/2297-8739/9/10/303
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