USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into the cytoplasm for ubiquitination and elimination by ER-associated degradation (ERAD). A surprising paradox emerging from recent studies is that ubiquitin ligases (E...

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Autores principales:	Yanfen Liu, Nia Soetandyo, Jin-gu Lee, Liping Liu, Yue Xu, William M Clemons Jr, Yihong Ye
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	eLife Sciences Publications Ltd 2014-01-01
Colección:	eLife
Materias:	ubiquitin ERAD deubiquitinase ubiquitin ligase Bag6 gp78
Acceso en línea:	https://elifesciences.org/articles/01369
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