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Efficient production of a cyclic dipeptide (cyclo-TA) using heterologous expression system of filamentous fungus Aspergillus oryzae

Abstract Background Cyclic dipeptides are an important class of natural products owing to their structural diversity and biological activities. In fungi, the cyclo-ring system is formed through the condensation of two α-amino acids via non-ribosomal peptide synthetase (NRPS). However, there are few...

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Hlavní autoři: Jianzhao Qi, Haiyan Han, Dan Sui, Shengnan Tan, Changli Liu, Pengchao Wang, Chunliang Xie, Xuekui Xia, Jin-ming Gao, Chengwei Liu
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2022-07-01
Edice:Microbial Cell Factories
Témata:
Aspergillus oryzae
Cyclic dipeptide
Echinulin
Heterologous expression
NRPS
On-line přístup:https://doi.org/10.1186/s12934-022-01872-8
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