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Droplet digital PCR as an alternative to FISH for MYCN amplification detection in human neuroblastoma FFPE samples

Abstract Background MYCN amplification directly correlates with the clinical course of neuroblastoma and poor patient survival, and serves as the most critical negative prognostic marker. Although fluorescence in situ hybridization (FISH) remains the gold standard for clinical diagnosis of MYCN stat...

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Autori principali: Dinesh Babu Somasundaram, Sheeja Aravindan, Zhongxin Yu, Muralidharan Jayaraman, Ngoc T. B. Tran, Shibo Li, Terence S. Herman, Natarajan Aravindan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-01-01
Serie:BMC Cancer
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Accesso online:http://link.springer.com/article/10.1186/s12885-019-5306-0
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